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University Of Alabama In Huntsville

301 Sparkman Dr
Huntsville, AL 35899

General Phone: 256-824-6120
Financial Aid Phone: 256-824-6241
Sector: Public, 4-year or above
Classification: Doctoral/Research Universities--Intensive

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Latest University Of Alabama In Huntsville News

Expression Genetics, Inc. Announces Enrollment of First Patients ... - PR Newswire (press release)

HUNTSVILLE, Ala., Oct. 17 /PRNewswire/ -- Expression Genetics, Inc. announced today that a Phase I clinical study evaluating the Company's lead drug candidate, EGEN-001, is underway at The University of Alabama at Birmingham in patients with recurrent epithelial ovarian cancer. The product formulated utilizing the Company's proprietary TheraPlas(TM) delivery technology is composed of interleukin-12 (IL-12) gene expression plasmid and a biocompatible delivery polymer and is designed to increase the local concentration of IL-12, a potent anti-cancer cytokine. TheraPlas(TM) is a novel polymeric- based system for delivery of nucleic acids to cells. Up to 18 patients will be enrolled in the open label, dose escalation study with safety as the primary endpoint. Plans are underway to open enrollment at a second site within a few weeks. EGEN-001 for treatment of ovarian cancer has been granted Orphan Drug Status by the FDA. "We are pleased to see our first TheraPlas(TM) candidate meet high expectations in the preclinical studies and now reach this important clinical milestone," said Danny H. Lewis, CEO and President of Expression Genetics. "Our goal is to provide patients and caregivers with another potent weapon against ovarian cancer and through continued testing ultimately use EGEN-001 to treat several different forms - more available